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This digital document is a journal article from Neuropsychologia, published by Elsevier in 2006. The article is delivered in HTML format and is available in your .com Media Library immediately after purchase. You can view it with any web browser.Description: In this study, we investigated the acquisition of affective dispositions towards neutral faces in patients with Alzheimer's disease and mixed dementia. Participants viewed four affectively neutral male faces from the International Affective Picture System. Biographical information about the depicted persons was presented, which described them in terms of positive or negative traits varying in intensity. Participants were asked to rate the pictures with respect to emotional valence, arousal, and preference prior to and after the presentation of the biographical information. Following a retention interval of 180min, pictures were rated again and the biographical information was presented once more. Final ratings were obtained after another interval of 1300min. As expected, healthy control participants identified the faces and recalled parts of the information in the delayed recall test. They showed pronounced changes in affective ratings. Patients did not recognize the faces in a recognition test after the retention intervals, but valence, arousal, and preference ratings were systematically altered by the affective content of biographies. The results suggest that acquisition and maintenance of implicit affective dispositions are preserved in dementia even when explicit memory is impaired.

This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in 2006. The article is delivered in HTML format and is available in your .com Media Library immediately after purchase. You can view it with any web browser.Description: To elucidate the involvement of endogenous estrogen (estradiol-17@b; E"2) and the decisive factor (somatic or germinal element) in the ovarian differentiation of tropical marine teleosts, the effect of the aromatase inhibitor (AI) fadrozole on gonadal sex differentiation in the golden rabbitfish Siganus guttatus (Bloch) was examined for different dosages and periods of treatment. Fadrozole interrupted ovarian cavity formation at a dose of 500 @mg g^-^1 diet, while there was little effect at 10 or 100 @mg g^-^1. The gonads from both the 30-day and 90-day administration (500 @mg g^-^1 diet) groups were significantly biased toward testes (P=0.002 and

This digital document is a journal article from Journal of Aging Studies, published by Elsevier in 2006. The article is delivered in HTML format and is available in your .com Media Library immediately after purchase. You can view it with any web browser.Description: The literature on caring for people with Alzheimer's disease predominantly underscores the role of the care giver, largely ignoring the care receiver. Care is viewed as a service to mind someone rather than a compassionate act of shared relationship. Alzheimer's disease is portrayed as negatively influencing reciprocity in caring relationships, precipitating their gradual dissolution. We report findings from an ethnographic study that followed nearly 100 dyads of people with Alzheimer's disease and those who cared for them for more than 1 year. 'Give and take' in a relationship appears richer and more ambiguous than previously supposed; despite one party's cognitive losses, shared meanings can still be experienced by both people. In an in-depth examination of the narratives of co-carers, gathered during home visits, relationships were seen to be dynamic co-constructions built upon everyday events, interactions, environments and disease progression. Importantly, we show that people with Alzheimer's disease express insight and awareness despite decline.

As image-guided spine interventions have increasingly become a primary strategy for managing back pain, the tools and capabilities available to practitioners have grown significantly. This fully revised edition of Image-Guided Spine Interventions presents the latest procedures available to physicians who perform minimally invasive spine interventions. The comprehensive text covers the fundamentalssuch as spine anatomy, procedural materials, and pharmacological requirementsalong with chapters devoted to key topics such as discography, percutaneous descectomy, vertebroplasty and balloon kyphoplasty, epidural steroid injections, and autonomic nerve blocks. Additionally, three new chapters are included in the Second Edition, covering pulsed radiofrequency procedures, sacroplasty, and spinal cord stimulation. Each technique is presented in a straightforward manner that allows the reader to effectively evaluate and implement new procedures. The text is further enhanced by nearly 200 images and illustrations. Edited by Dr. John Mathis, a former president of the American Society of Spine Radiology, and Dr. Stanley Golovac, who both have clinical practices devoted solely to spine procedures and pain management, the book will be useful to all physicians dealing with back pain, including radiologists, pain anesthesiologists, spine neurosurgeons, and orthopedists. Physicians will once again find that Image-Guided Spine Interventions, 2nd Edition, is the pivotal authority on image-guided techniques for the spine.

In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

Migraine is an extremely common condition affecting 28 million Americans. Fully 1 in every 6 adult women suffers from this malady. Patients with migraine are frequently seen in the Emergency Room and Urgent Care Clinic for acute treatment of their headaches. Headache generally accounts for nearly 3 % of all ER visits, resulting in almost 3.5 million visits annually. There currently are no widely used guidelines for the treatment of patients with headache in the ER or UCC, and reducing the number of CT scans remains a key goal for administrators in many ER or urgent care settings. In one study, 35 drugs, alone or in combination, were used to treat migraine. The most common medication class used was narcotics, which were used in 25% of the visits. The next two most commonly used classes were antiemetics and NSAIDs. Only 5% of patients seen for headache received headache-specific medications during their visit. ER and Urgent Care physicians generally have little or no formal training in treating these patients. Consequently, they often feel less comfortable ruling out secondary causes of headaches and using appropriate headache treatment medications and procedures. Since many patients have received narcotics in previous visits, providers may view them as drug seekers. Patients seen in ERs and UCCs for acute treatment of their headaches often report high levels of dissatisfaction. They often end up in the ER or UCC because they dont have a formal treatment strategy for their severe headaches. Health plans and insurance agencies are often frustrated by the high cost of fragmented care for patients with headaches. Because of the environment that most ER and UCC providers operate in, many unnecessary scans and tests are done because of uncertainty of the diagnosis and unfamiliarity of the patient. Primary care physicians are also frustrated by patients with headaches presenting to them after being seen in the ER or UCC, wanting a refill of their narcotics that they were given. Many patients dont follow up with their PCPs and simply keep returning to the ER/UCC for their treatment. In short, all involved in the care for patients with headache are frustrated by the current system. The care for these patients is clearly not optimal. It doesnt have to be that way. There are a wide variety of effective treatment options available, but are underutilized in the acute setting. With these treatment options, patients no longer have to be treated only with parenteral narcotics, only to perpetuate the cycle of suboptimal care described above. This concise handbook covers all aspects of acute headache care, including care of the child and adolescent with acute headaches, treatment of pregnant and breastfeeding women with acute headaches and appropriate evaluation of secondary headaches. In addition, two other novel chapters are included: one on caring for older patients with acute headaches as well as a chapter describing how to ensure a seamless transition of the patient back to a headache interested provider. Representing an important milestone in the care of patients with headache, this is the first concise handbook available to exclusively address the issue of headache treatment in the acute care setting. Including protocols and strategies that can be used right away, Management of Headaches in Emergency Room and Urgent Care Settings: Diagnosis and Management provides information about lesser known, but effective strategies such as greater occipital nerve blocks that can be easily learned and incorporated in the acute care setting. It emphasizes the continuity of care that is so vital to keep headache patients from returning to the ER and UCC for acute treatment.

Spinal Injections & Peripheral Nerve Blocks- a volume in the new Interventional and Neuromodulatory Techniques for Pain Management series - presents state-of-the-art guidance on when and why these procedures should be performed, the mechanisms of action on pain, and current guidelines for practice. Honorio Benzon, MD; Marc Huntoon, MD; and Samer Nauroze, MD offer expert advice and scientific evidence supporting the use of spinal injections and sympathetic nerve blocks. Comprehensive, evidence-based coverage on selecting and performing these techniques - as well as weighing relative risks and complications - helps you ensure optimum outcomes. With access to the fully searchable text at www.expertconsult.com and procedural videos on Expert Consult, you'll have the detailed visual assistance you need right at your fingertips. Understand the rationale and scientific evidence behind spinal injections and sympathetic nerve blocks - when and why they should be performed, the mechanisms of action on pain, and current guidelines for practice - and master their execution. Optimize outcomes, reduce complications, and minimize risks by adhering to current, evidence-based practice guidelines. Apply the newest techniques in employing ultrasound, fluoroscopy and computed tomography(CT) to guide needle placement. Quickly find the information you need in a user-friendly format with strictly templated chapters supplemented with illustrative line drawings, images, and treatment algorithms. See how it's done through step-by-step procedural videos on Expert Consult. Access the fully searchable contents at expertconsult.com. Improve patient safety and minimize risks with evidence-based, step-by-step guidance for interventional and neuromodulatory techniques

Since PET was first introduced clinically, brain tumors have been an important area for its use. Diagnosing the cause of patients experiencing seizures has been an additional area for which PET has demonstrated its value. PET imaging is also being investigated for the understanding of depression and other psychiatric dis

Gastrointestinal and Liver Pathology, a title in the Foundations in Diagnostic Pathology series, provides all the most essential information on the pathological entities encountered in practice in an easy-to-use format. Drs. Christine A. Iacobuzio-Donahue and Elizabeth Montgomery examine the full scope of neoplastic and non-neoplastic dis

This combination manual and DVD provides much-needed training on the proper handling of rats used in biomedical research. The DVD includes narrated video clips that demonstrate and describe each procedural technique. The manual contains handouts with color illustrations and descriptive text for each technique, including the purpose and application of the procedure, recommended skills, and necessary supplies. It can be used as a training resource and refresher for lab animal veterinarians, veterinary technicians, animal care staff, trainers, and research investigators and staff who work with rats.